Compounded Vaginal Estradiol Cream

$89 / 30-day supply (16ml)

A prescription vaginal cream with estradiol 0.04% that delivers estrogen locally to help relieve vaginal dryness, irritation, painful sex, and certain urinary symptoms associated with declining estrogen during perimenopause and menopause.*

Book a visit

Science

How To Use

The cream comes in a metered dispenser. Each turn of the dispenser is called a click, and each click releases a measured amount of cream. This allows the clinician to prescribe a specific amount and gives the patient a consistent way to measure each dose.

Your Midi clinician will tell you exactly how many clicks to use, where to apply the cream, and how often to use it. A common treatment approach begins with more frequent use for the first few weeks to help restore estrogen-depleted tissue, followed by a smaller maintenance dose a few times per week.

Use the cream as directed, including on external vulvar tissue if recommended by your clinician.

Applying it at bedtime may help the cream stay in place. Wash your hands before and after application.

If you use latex condoms or a diaphragm, talk with your clinician or pharmacist because oil-based creams can weaken latex.

Benefits

Midi’s Compounded Vaginal Estradiol Cream may help:

- Relieve vaginal dryness, burning, and irritation, itching (GSM)

- Restore natural moisture and lubrication

- Support healthier, more resilient vaginal and vulvar tissue

- Reduce pain and discomfort during sex

- Relieve certain urinary symptoms associated with menopause

Book A Visit

How Compounded Vaginal Estradiol Cream Works

Estrogen helps keep vaginal and urinary tissues healthy, moisturized, elastic, and resilient. As estrogen declines during perimenopause and menopause, these tissues can become thinner, drier, and more fragile.

These changes can cause vaginal dryness, burning or irritation, less natural lubrication, pain during sex, and urinary symptoms such as urgency and frequency. These are also known as genitourinary syndrome of menopause (GSM). Unlike some menopause symptoms that may improve over time, GSM can persist or worsen without treatment.

Vaginal estradiol delivers estrogen directly to vaginal and vulvar tissues affected by estrogen decline. There, estradiol acts on estrogen receptors to help restore tissue that can become thinner, drier, and less elastic during perimenopause and menopause.

Over time, this helps improve tissue health and resilience, restore natural moisture and lubrication, and relieve symptoms like dryness, irritation, and pain during sex. Because estrogen also supports tissues around the urethra and lower urinary tract, vaginal estradiol may also help improve certain urinary symptoms associated with menopause.*

Active ingredient : Estradiol 0.04%

Estradiol is the same type of estrogen naturally produced by the ovaries. Here, it is delivered directly to the vaginal and vulvar tissues to help restore changes caused by declining estrogen.

Ellage cream base: Medium-Chain Triglycerides NF, Hard Fat NF, Polyoxyl Stearate NF, Glyceryl Monostearate NF, Poloxamer 407 NF, Glyceryl Ricinoleate, and Polyoxyl Cetostearyl Ether NF.

Easy as 1, 2, 3

Midi Custom Rx

Book Your First Visit

Meet Your Clinician

Start Your Care Plan

Book a visit

FAQs

What is vaginal estradiol?

Is vaginal estradiol different from systemic hormone replacement therapy? Can I use both?

How is vaginal estradiol different from vaginal moisturizers and lubricants?

Can I use vaginal estradiol with other menopause treatments?

Can I use vaginal estradiol with Midi DHEA/Estradiol Cream?

Vaginal estradiol and Midi DHEA/Estradiol Cream address different needs and may be used together when clinically appropriate. Vaginal estradiol is used to address estrogen-related vaginal and urinary tissue changes. Midi DHEA/Estradiol Cream is applied externally to the vulva and is designed to support vulvar tissue, vaginal dryness, painful sex, and libido.
Your Midi clinician can determine which treatment or combination is appropriate based on your symptoms.

Will vaginal estradiol help with hot flashes, mood, or bone density?

No. Low-dose vaginal estrogen is a local therapy designed to treat vaginal, vulvar, and certain urinary symptoms associated with estrogen decline. It is not intended to treat systemic menopause symptoms or provide the systemic benefits of hormone therapy. Symptoms such as hot flashes and night sweats generally require systemic treatment. Your Midi clinician can determine which type of hormone therapy is appropriate based on your symptoms and health history.

Can vaginal estradiol help with urinary symptoms?

What are common side effects?

Can I use vaginal estradiol if I’ve had breast cancer?

The sources behind the science

*Not available in all 50 states. Compounded drug products are not FDA approved. The FDA does not evaluate compounded drug products for safety, effectiveness, or quality. Prescription products require an online consultation with a healthcare provider, who will determine if an individual is eligible for a prescription if medically appropriate in their independent clinical judgement. Full safety information, provider consultation requirements, and restrictions, are available at https://www.joinmidi.com/.