Up to 4x
Women with no prior history of depression are two to four times more likely to experience a major depressive episode during perimenopause or postmenopause.²
Mood_swings
If your mood swings have mood swings — let's talk
Up to 60% of women experience anxiety, irritability, and mood swings with hormone changes.¹ Find relief with our insurance-covered Care Plans.
Why is this happening?
Estrogen shifts affect serotonin and dopamine (your mood chemicals), while a drop in progesterone quiets GABA (your calming signal).
Emotional symptoms are as real as physical ones. Relief starts by treating your brain and body together.
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Up to 4x
Women with no prior history of depression are two to four times more likely to experience a major depressive episode during perimenopause or postmenopause.²
Is stress suddenly harder to shake?
It's because your nervous system is working overtime.
When hormone levels fluctuate, your brain has to work harder to find a new emotional baseline.
Estrogen shifts affect serotonin and dopamine (your mood chemicals), while a drop in progesterone quiets GABA (your calming signal).
When those systems dip at the same time, it can leave you anxious, irritable, or on edge.
Emotional symptoms are as real as physical ones. Relief starts by treating your brain and body together.
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Your mind is one of a kind. So is your Midi Care Plan.
Mood swings are not just a side effect of aging. It’s a complex neurological shift that deserves dedicated attention. Our clinicians examine and treat the biology behind symptoms to help you feel grounded, steady, and more like yourself again.
How we build your Care Plan
Midi clinicians support you from every angle. They start by listening — then draw on the options below to build the right plan for you.
1Labs & testing
View details
1Labs & testing
We support you with things like:
- Complete blood count and ferritin
- Comprehensive metabolic panel
- Thyroid panel
2Lifestyle coaching & support
View details
2Lifestyle coaching & support
We support you with things like:
- Referrals for therapy and cognitive behavioral health
- Stress management
- Sleep hygiene
Anna Lederman, MSN, APRN, CNM
3Hormone prescriptions
View details
3Hormone prescriptions
We support you with things like:
- Estradiol
- Progesterone
More to explore:
What is HRT?
4Non-hormone prescriptions
View details
4Non-hormone prescriptions
We support you with daily medications, including antidepressants like:
- SSRIs
- SNRIs
5Supplement integration
View details
5Supplement integration
We support you with things like:
- Daily Brain Boost
- Daily Cortisol Support
More to explore:
Shop Midi productsReal women. Real relief.
No more crazy anxiety attacks, no more sleepless nights no more dry itchy skin.
I would become emotional for no reason—sometimes wanting to cry, other times just feeling sad and overwhelmed.
I can sleep, workout, no headaches, minimal anxiety/depression, and I feel like my old self.
The anxiety and depression that once felt so overwhelming are no longer controlling my life.
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Products made for mood swings
Clinically informed. Research-backed.
Shop all Midi products
More on the Midi Mag
Menopause and your mood: How shifting hormones influence mental health
Sept 6, 2022
Mood changes aren't all in your head. They're driven by shifting hormones and neurotransmitters. The silver living? Relief is closer than you think.
Midi's complete guide to perimenopause anxiety: causes, symptoms, and solutions
Aug, 26, 2025
Feeling perpetually on edge, overwhelmed, or worried? That perimenopausal anxiety. Here's what causes it, and how to find relief.
Menopause and anger towards husbands and partners: Fact or fiction?
Sept 15, 2024
Experiencing perimenopause rage—that intense anger that seems to come out of nowhere? You're far from alone, and you're not overreacting. These emotional changes are a common but often overlooked symptom of the menopause transition.
Sources & Citations
1. 1. Freeman, E. W., Sammel, M. D., Lin, H., & Nelson, D. B. (2006). Associations of hormones and menopausal status with depressed mood in women with no history of depression. Archives of General Psychiatry, 63(4), 375–382. https://doi.org/10.1001/archpsyc.63.4.375
2. Bromberger, J. T., & Kravitz, H. M. (2011). Mood and menopause: Findings from the Study of Women's Health Across the Nation (SWAN) over ten years. Obstetrics and Gynecology Clinics of North America, 38(3), 609–625. https://doi.org/10.1016/j.ogc.2011.05.011
Get back to your emotional baseline
Midi accepts most major health plans. Book a virtual visit and start feeling like yourself again.