Up to 4x
Women with no prior history of depression are two to four times more likely to experience a major depressive episode during perimenopause or postmenopause.3
Mood_swings
If your mood swings have mood swings — let's talk
58% of perimenopausal women report experiencing significant irritability, mood swings, or heightened anxiety during the menopausal transition.¹ Find relief with our insurance-covered Care Plans.²
Why is this happening?
Estrogen shifts affect serotonin and dopamine (your mood chemicals), while a drop in progesterone quiets GABA (your calming signal)
Emotional symptoms are as real as physical ones Relief starts by treating your brain and body together
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Up to 4x
Women with no prior history of depression are two to four times more likely to experience a major depressive episode during perimenopause or postmenopause.3
Is stress suddenly harder to shake?
It's because your nervous system is working overtime.
When hormone levels fluctuate, your brain has to work harder to find a new emotional baseline.
Estrogen shifts affect serotonin and dopamine (your mood chemicals), while a drop in progesterone quiets GABA (your calming signal)
When those systems dip at the same time, it can leave you anxious, irritable, or on edge
Emotional symptoms are as real as physical ones Relief starts by treating your brain and body together
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Your mind is one of a kind. So is your Midi Care Plan.
Mood swings are not just a side effect of aging. It’s a complex neurological shift that deserves dedicated attention. Our clinicians examine and treat the biology behind symptoms to help you feel grounded, steady, and more like yourself again.
How we build your Care Plan
Midi clinicians support you from every angle. They start by listening — then draw on the options below to build the right plan for you.
Labs & testing
View details
Labs & testing
We support you with things like:
- Complete blood count and ferritin
- Comprehensive metabolic panel
- Thyroid panel
Lifestyle coaching & support
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Lifestyle coaching & support
We support you with things like:
- Referrals for therapy and cognitive behavioral health
- Stress management
- Sleep hygiene
Anna Lederman, MSN, APRN, CNM
Hormone prescriptions
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Hormone prescriptions
We support you with things like:
- Estradiol
- Progesterone
More to explore:
What is HRT?
Non-hormone prescriptions
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Non-hormone prescriptions
We support you with daily medications, including antidepressants like:
- SSRIs
- SNRIs
Supplement integration
View details
Supplement integration
We support you with things like:
- Daily Brain Boost
- Daily Cortisol Support
More to explore:
Shop Midi productsReal Midi Patients. Real relief*.
One minute I felt rage — the next deep sadness. I was isolating and losing myself. Finding Midi was a turning point.
After about 1 week, I felt more like myself again. Even my coworkers noticed how much happier I seemed.
I'm no longer constantly irritable with my family. I can fully enjoy being connected to my partner again.
From vertigo to mood swings, nearly all my symptoms have improved. I am not exaggerating when I say Midi saved my life.
After seeing multiple specialists for panic attacks and heart palpitations, Midi finally gave me my life back.
No more crazy anxiety attacks, no more sleepless nights, no more dry, itchy skin.
I was hot, mean, and begging for someone to listen. Within a month of starting HRT, I saw a huge difference.
After about a month, I had more energy and less anxiety. Later, my hot flashes were gone and I finally slept all night.
At 42, it felt like a stranger had taken over my body. Starting HRT helped me finally feel like myself again.
I had digestive issues. My ears were dry and itchy! I was depressed, finding little joy in life.
We need to stop treating perimenopause and menopause care like it’s optional — or worse, cosmetic.
I wanted a clinician with midlife expertise who was up to date on the science. I found her at Midi — she’s amazing.
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Products made for mood swings
Clinically informed. Research-backed.
More on Midi Mag
Menopause and your mood: how shifting hormones influence mental health
Sept 6, 2022
Mood changes aren't all in your head. They're driven by shifting hormones and neurotransmitters. The silver living? Relief is closer than you think.
Midi's complete guide to perimenopause anxiety: causes, symptoms, and solutions
Aug, 26, 2025
Feeling perpetually on edge, overwhelmed, or worried? That perimenopausal anxiety. Here's what causes it, and how to find relief.
Menopause and anger towards husbands and partners: Fact or fiction?
Sept 15, 2024
Experiencing perimenopause rage—that intense anger that seems to come out of nowhere? You're far from alone, and you're not overreacting. These emotional changes are a common but often overlooked symptom of the menopause transition.
Sources & citations
1. Citation: Kravitz, H. M., et al. / SWAN Study. Obstetrics and Gynecology Clinics, 38(3), 537–550).
2. Midi is in-network with most major insurance providers nationwide, but coverage depends on your specific plan — deductibles, coinsurance, and copays vary and may still apply. Check your plan for details specific to you. Self-pay options are also available.
3. Bromberger, J. T., & Kravitz, H. M. (2011). Mood and menopause: Findings from the Study of Women's Health Across the Nation (SWAN) over ten years. Obstetrics and Gynecology Clinics of North America, 38(3), 609–625. https://doi.org/10.1016/j.ogc.2011.05.011
*These real patients became Midi Ambassadors and may receive free products and/or swag. Individual results may vary.
Get back to your emotional baseline
Midi accepts most major health plans. Book a virtual visit and start feeling like yourself again.