Midi Custom Rx - Sexual Health

DHEA/Estradiol Cream

30-day supply (30ml)

A targeted cream designed to rejuvenate the vulvar tissues and support libido.

Your clinician will evaluate your medical history and symptoms to determine if this prescription is right for you.
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Improves vaginal dryness and painful sex.


DHEA/Estradiol Cream


What to expect

Prior to menopause, estrogen helps to keep the skin of your vagina and vulva lubricated, thick, and elastic. For many women, the gradual drop in estrogen that happens during perimenopause and menopause can cause the vaginal walls to become thin, dry, and prone to irritation, leading to painful sex and other problems.

Dehydroepiandrosterone (DHEA), a hormone produced by the adrenal glands, can be converted to estrogen and testosterone. When used as a topical cream, it has been shown to improve symptoms of vaginal dryness and painful intercourse. 

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What are the benefits of DHEA/Estradiol Cream?

  • Improves painful intercourse and vaginal dryness caused by estrogen-related thinning and drying of the vaginal walls

Is DHEA/Estradiol Cream right for me?

Book a visit with your Midi Clinician. Once you’ve reviewed your medical history and current symptoms together, your clinician will advise on whether this might be a helpful treatment. She may also recommend additional solutions that support sexual health.

How should I apply DHEA/Estradiol Cream?

Apply the cream to the external vulva once daily. Wash your hands after application and wait 20 minutes before sexual activity.

What are the ingredients in DHEA/Estradiol Cream?

Active Ingredients: DHEA 0.75%, Estradiol .01%

Full Ingredients: DHEA, Estriol, Ethoxy Dicglycol, Versapro Cream Base (Aloe Barbadensis Leaf Juice, Cyclopentasiloxane, Disodium EDTA, Emulsifying Wax NF, Ethylhexylglycerin, Ethylhexyl Stearate, Glycerin, Phenoxyethanol, Sorbitol, Tocopheryl Acetate, Water

Can women with hormone-sensitive breast cancer or gynecological cancers use DHEA/Estradiol Cream?

Yes, survivors and women being treated for hormone-sensitive breast cancer or gynecological cancers may use the cream (apply only to the external vulva).

Can I use systemic hormone therapy while using DHEA/Estradiol Cream?

Yes, systemic hormone therapy and DHEA Cream may be used together.

Can I use localized vaginal estrogen while using DHEA/Estradiol Cream?

Yes, localized vaginal estrogen and DHEA/Estradiol Cream may be used together. DHEA/Estradiol Cream is applied to the external vulva and vaginal estradiol is applied inside the vagina.

Can I use localized Intrarosa while using DHEA/ Estradiol Cream?

Yes, Intrarosa and DHEA/Estradiol Cream may be used together. DHEA/Estradiol Cream is applied to the external vulva and Intrarosa is applied inside the vagina. 

What should I know about safety?

  • Research has found vaginal DHEA to be an effective and safe treatment for symptoms of vaginal dryness in menopausal women. Cancer survivors may also use the cream.
  • Side effects may include external itching and vaginal discharge. 
  • If you have a known allergic reaction to any of the ingredients in DHEA/Estradiol Cream, do not use this product.
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FAQs for current patients can be found here.
For any additional questions, please email us at care@joinmidi.com

Midi Custom Rx

Midi Custom Rx offers a range of products for skin, hair, and sexual health, prescribed by your Midi clinician, and shipped directly to you from Midi’s own formulary.

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Our Custom Rx treatments are prescribed by your licensed Midi clinician.

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