DHEA/Estradiol

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Compounded Formulations:

DHEA 5mg + Estradiol 0.1mg/ml VaginalCream

FDA Approval:

  • Estradiol
    • Vulvar and vaginal atrophy associated with menopause
  • DHEA
    • Dyspareunia secondary to vulvar and vaginal atrophy due to menopause

Mechanism of Action:

  • Estradiol
    • Local estrogens have been shown to reduce vaginal pH as well as mature the vaginal and urethral mucosa to improve vaginal dryness and mucosal atrophy.
  • DHEA
    • DHEA itself a natural hormone that helps produce both testosterone and estrogen, both of which help with collagen and elasticity. DHEA is often used as a testosterone booster as well.

Benefits:

  • Vaginal Dryness
    • Topical estrogen may improve vaginal lubrication through decreased vaginal pH, increased blood flow, and lubrication.
    • Subsequently women have reported decreased vaginal irritation leading to increased sexual desire and quality of life.
  • Libido
    • Topical estrogen and DHEA improves vaginal health. Additionally the DHEA is a precursor to testosterone, which may improve sexual health.

Suggested Dosing:

  • Apply 1 gram to labia, vulva and vaginal vestibule.

Storage/Stability:

  • Store in the original container at 68°F to 77° away from heat, moisture, and light.

Breastfeeding:

  • Estrogens are present in breastmilk and have been shown to decrease the quantity and quality of human milk.

Drug interactions:

  • Anastrozole (Estradiol)
  • Cosyntropin (Estradiol)
  • Exemestane (Estradiol)
  • Fexinidazole (Estradiol)
  • Fezolinetant (Estradiol)
  • FusidicAcid (Estradiol)
  • Growth Hormone Analogs (Estradiol)
  • Hemin (Estradiol)
  • Indium 111 Capromab Pendetide (Estradiol)
  • Metyrapone (Estradiol)
  • Ospemifene (Estradiol)
  • Raloxifene (Estradiol)
  • Tizanidine (Estradiol)
  • Tranexamic Acid (Estradiol)