Midi Custom Rx - Age Defense

Estriol+ Face Cream

90-day supply (3 pump dispensers, 30ml each)

A moisture-rich cream that firms, plumps, and brightens skin while smoothing fine lines and reducing pore size.

Your clinician will evaluate your medical history and symptoms to determine if this prescription is right for you.
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Reduces wrinkle depth and pore size, restores moisture, and increases skin firmness and elasticity.


Estriol+ Face Cream


What to expect

As estrogen levels drop during the menopause transition, your skin loses collagen, elastin, and lubrication, leading to thinning, sagging, and wrinkles along with drier, flakier skin.

Topical use of estrogen has been shown to improve collagen and elastin levels in menopausal women, as well as moisturizing the skin. When applied to the face, estriol can help minimize fine lines, plump and tighten skin. This formulation also contains hyaluronic acid and DMAE. Hyaluronic acid adds an extra boost of moisture while DMAE brightens and evens skin tone.


Estriol (E3) is the weakest of the three estrogen hormones. It does not increase the level of hormones circulating throughout your body when used topically, making it a safe option for most women.

Learn more about the product


What are the benefits of Estriol+ Face Cream?

  • Targets skin changes related to estrogen decline, including dryness, thinning, and wrinkles
  • Renews firmness and smooths texture
  • Brightens and evens the complexion
  • Minimizes fine lines and wrinkles

Is Estriol+ Face Cream right for me?

To determine if Estriol+ Face Cream is appropriate for you, book a visit with a Midi clinician. Once you’ve reviewed your medical history and current symptoms together, your clinician will advise on whether this might be a helpful addition to your skin regimen. She may also recommend additional solutions that support skin health.

How should I apply Estriol+ Face Cream?

Apply to the face and neck once daily. Smooth onto clean, dry skin, wait for the cream to absorb fully, then follow with any other skincare products and/or makeup.

What are the ingredients in Estriol+ Face Cream?

Active ingredients: Estriol 0.3%, DMAE 0.3%, Hyaluronic Acid 0.5%

Full Ingredients: Estriol, Dimethylaminoethanol, Sodium Hyaluronate, Ethoxy Diglycol (inactive), Emollient Cream Base (Purified Water, White Petrolatum, Cetyl Alcohol, Stearyl Alcohol, Propylene Glycol, Glycerin, Sodium Lauryl Sulfate, Diazolidinyl Urea, Iodopropynyl Butylcarbamate) Estriol, Dimethylaminoethanol, Sodium Hyaluronate,

Can I use retinol while using Estriol+ Face Cream?

Yes. In fact, the hydrating benefits of this cream may balance the drying effects of retinol. Some women choose to alternate use of the creams while others use both daily.

What should I know about safety?

  • If you have a known allergic reaction to estriol or any other ingredients in the cream, do not use Estriol+ Face Cream. Your clinician will ensure that estriol is right for you before prescribing this product. 
  • Estriol may enhance pigmentation, exacerbating melasma (age spots). We’ve formulated this product with brightening ingredients (DMAE) to counteract this, but you may want to avoid applying the cream to areas prone to hyperpigmentation. 
  • Do not use the product on open skin wounds, active skin diseases (such as scleroderma) or if you’re receiving radiation therapy to the same skin area.
  • Women who are pregnant should avoid using this product.

What research & studies are associated with Estriol?

Effect of estrogens on skin aging and the potential role of SERMs

"In humans, structural and functional changes attributable to aging are more visibly evident in the skin than in any other organ. Estrogens have significant effects on skin physiology and modulate epidermal keratinocytes, dermal fibroblasts and melanocytes, ..." read more

Estrogen-deficient skin: The role of topical therapy

"Menopause is a major turning point in a woman’s life that is characterized by declining ovarian function and decreased serum estrogen levels. The resulting hormonal changes particularly affect the skin, with postmenopausal symptoms such as loss ..." read more

Treatment of skin aging with topical estrogens

"After treatment for 6 months, elasticity and firmness of the skin had markedly improved and the wrinkle depth and pore sizes had decreased by 61 to 100% in both groups. Furthermore, skin moisture had increased and the measurement of wrinkles using skin profilometry, revealed significant, or even…" read more

Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin

"Dermatology and Therapy - Estrogen is a pivotal signaling molecule; its production is regulated by the expression of the aromatase (CYP19A1) gene from ovarian and peripheral tissue sites, and it is..." read moreView product monogra

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Midi Custom Rx

Midi Custom Rx offers a range of products for skin, hair, and sexual health, prescribed by your Midi clinician, and shipped directly to you from Midi’s own formulary.

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