Dark Spot: Hydroquinone Cream

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. The following information has been provided by the package inserts.

Compounded Formulations:

Hydroquinone Ascorbic Acid Niacinamide Cream

FDA Approval:

  • Topical skin lightening agent (Hydroquinone)
  • The FDA does not currently require approval for vitamins and/or supplements (Ascorbic Acid and Niacinamide)

Mechanism of Action:

  • Hydroquinone – reduces melanin pigment production through inhibition of the tyrosinase enzyme, which is involved in the initial step of the melanin pigment biosynthesis pathway.  
  • Ascorbic Acid – assists in lightening dark patches on skin
  • Niacinamide – blocks enzymes associated with skin discoloration


  • Hydroquinone combination therapies may significantly decrease lesion size, pigmentation, and disease severity in those with post inflammatory hyperpigmentation.
  • Over a 3-month treatment period, 70% of melasma patients experience reduced or cleared pigmentation.
  • May improve skin texture

Warning / Contraindications:

  • Avoid sun exposure or use sun protection

Suggested Dosing:

  • Melasma - Apply one pump of cream to the affected area (face) at night time.


  • Topical
  • Apply to clean and dry affected area
  • Use medication for 4 months consecutively, and take 1 month off period to risk of rebound hyperpigmentation


  • Room Temperature
  • Protect from moisture and excessive heat
  • Beyond Use Date: 6 months (180 days)


  • Not recommended during pregnancy


  • It is not known if present in breast milk, use with caution

Side Effects:

  • Abdominal pain
  • Dry mouth